Isaac married Mary Barker, daughter of John Barker and Margaret, on 20 May 1622 in , , Eng. (Mary Barker was born on 1 Jan 1604 in Stoke By Nayland, Sudbury, Suffolk, Eng, christened on 16 Sep 1594, died on 23 Apr 1677 in Watertown, Ma and was buried in Apr 1677.)
